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The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA
The metabolite (–)-lomaiviticin A, which contains two diazotetrahydrobenzo[b]fluorene (diazofluorene) functional groups, inhibits the growth of cultured human cancer cells at nanomolar–picomolar concentrations; however, the mechanism responsible for the potent cytotoxicity of this natural product is...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090708/ https://ncbi.nlm.nih.gov/pubmed/24848236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1944 |
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