Metadynamics Simulation Study on the Conformational Transformation of HhaI Methyltransferase: An Induced-Fit Base-Flipping Hypothesis

DNA methyltransferases play crucial roles in establishing and maintenance of DNA methylation, which is an important epigenetic mark. Flipping the target cytosine out of the DNA helical stack and into the active site of protein provides DNA methyltransferases with an opportunity to access and modify...

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Hlavní autoři: Jin, Lu, Ye, Fei, Zhao, Dan, Chen, Shijie, Zhu, Kongkai, Zheng, Mingyue, Jiang, Ren-Wang, Jiang, Hualiang, Luo, Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090504/
https://ncbi.nlm.nih.gov/pubmed/25045662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/304563
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