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Metadynamics Simulation Study on the Conformational Transformation of HhaI Methyltransferase: An Induced-Fit Base-Flipping Hypothesis

DNA methyltransferases play crucial roles in establishing and maintenance of DNA methylation, which is an important epigenetic mark. Flipping the target cytosine out of the DNA helical stack and into the active site of protein provides DNA methyltransferases with an opportunity to access and modify...

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Библиографические подробности
Главные авторы: Jin, Lu, Ye, Fei, Zhao, Dan, Chen, Shijie, Zhu, Kongkai, Zheng, Mingyue, Jiang, Ren-Wang, Jiang, Hualiang, Luo, Cheng
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090504/
https://ncbi.nlm.nih.gov/pubmed/25045662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/304563
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