Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis

Colitis-associated colon cancer (CAC) develops as a result of inflammation-induced epithelial transformation, which occurs in response to inflammatory cytokine-dependent downregulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and subsequent suppression of prostaglandin metabolism. Agents t...

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Autores principales: Choi, Sung Hee, Kim, Byung-Gyu, Robinson, Janet, Fink, Steve, Yan, Min, Sporn, Michael B., Markowitz, Sanford D., Letterio, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089461/
https://ncbi.nlm.nih.gov/pubmed/24837432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69672
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