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Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis
Colitis-associated colon cancer (CAC) develops as a result of inflammation-induced epithelial transformation, which occurs in response to inflammatory cytokine-dependent downregulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and subsequent suppression of prostaglandin metabolism. Agents t...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089461/ https://ncbi.nlm.nih.gov/pubmed/24837432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69672 |
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