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The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb

The KIX domain is a mediator of the interaction between different transcription factors. This complex function is carried out via two distinct binding sites located on opposite sides of the protein; namely, the ‘c-Myb site’ and the ‘MLL site’, named after their characteristic ligands—the transactiva...

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Hlavní autoři: Toto, Angelo, Giri, Rajanish, Brunori, Maurizio, Gianni, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088980/
https://ncbi.nlm.nih.gov/pubmed/24753318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2480
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