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Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system

A classical dogma of molecular biology dictates that the 3D structure of a protein is necessary for its function. However, a considerable fraction of the human proteome, although functional, does not adopt a defined folded state under physiological conditions. These intrinsically disordered proteins...

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Detalhes bibliográficos
Main Authors: Giri, Rajanish, Morrone, Angela, Toto, Angelo, Brunori, Maurizio, Gianni, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773806/
https://ncbi.nlm.nih.gov/pubmed/23980173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307337110
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