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Reassessing the folding of the KIX domain: Evidence for a two-state mechanism

The debate about the presence and role of intermediates in the folding of proteins has been a critical issue, especially for fast folders. One of the classical methodologies to identify such metastable species is the “burst-phase analysis,” whereby the observed signal amplitude from stopped-flow tra...

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Hlavní autoři: Morrone, Angela, Giri, Rajanish, Brunori, Maurizio, Gianni, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527714/
https://ncbi.nlm.nih.gov/pubmed/23011783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2159
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