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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
The β-site APP cleaving enzymes 1 and 2 (BACE1 and BACE2) were initially identified as transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE1 is a major drug target for Alzheimer’s disease because BACE1-mediated cleavage of APP is the first step in the generation of the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086641/ https://ncbi.nlm.nih.gov/pubmed/24646365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12715 |
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