Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging because of low CSF volume, low total protein concentration, and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantit...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Dislich, Bastian, Wohlrab, Felix, Bachhuber, Teresa, Müller, Stephan A., Kuhn, Peer-Hendrik, Hogl, Sebastian, Meyer-Luehmann, Melanie, Lichtenthaler, Stefan F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597136/
https://ncbi.nlm.nih.gov/pubmed/26139848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.041533
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