Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

Cell surface proteolysis is essential for communication between cells and results in the shedding of membrane-protein ectodomains. However, physiological substrates of the contributing proteases are largely unknown. We developed the secretome protein enrichment with click sugars (SPECS) method, whic...

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Detalhes bibliográficos
Main Authors: Kuhn, Peer-Hendrik, Koroniak, Katarzyna, Hogl, Sebastian, Colombo, Alessio, Zeitschel, Ulrike, Willem, Michael, Volbracht, Christiane, Schepers, Ute, Imhof, Axel, Hoffmeister, Albrecht, Haass, Christian, Roßner, Steffen, Bräse, Stefan, Lichtenthaler, Stefan F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400020/
https://ncbi.nlm.nih.gov/pubmed/22728825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.173
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