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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

The β-site APP cleaving enzymes 1 and 2 (BACE1 and BACE2) were initially identified as transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE1 is a major drug target for Alzheimer’s disease because BACE1-mediated cleavage of APP is the first step in the generation of the...

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Bibliografiske detaljer
Main Authors: Vassar, Robert, Kuhn, Peer-Hendrik, Haass, Christian, Kennedy, Matthew E., Rajendran, Lawrence, Wong, Philip C., Lichtenthaler, Stefan F.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086641/
https://ncbi.nlm.nih.gov/pubmed/24646365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12715
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