Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging because of low CSF volume, low total protein concentration, and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantit...

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Опубликовано в: :Mol Cell Proteomics
Главные авторы: Dislich, Bastian, Wohlrab, Felix, Bachhuber, Teresa, Müller, Stephan A., Kuhn, Peer-Hendrik, Hogl, Sebastian, Meyer-Luehmann, Melanie, Lichtenthaler, Stefan F.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2015
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597136/
https://ncbi.nlm.nih.gov/pubmed/26139848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.041533
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