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Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

BACKGROUND: The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined. RESULTS: We used primary neurons and mouse brain slices to show that SET is...

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Detalhes bibliográficos
Main Authors: Chasseigneaux, Stéphanie, Clamagirand, Christine, Huguet, Léa, Gorisse-Hussonnois, Lucie, Rose, Christiane, Allinquant, Bernadette
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086270/
https://ncbi.nlm.nih.gov/pubmed/24981783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-82
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