Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

BACKGROUND: The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined. RESULTS: We used primary neurons and mouse brain slices to show that SET is...

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Hauptverfasser: Chasseigneaux, Stéphanie, Clamagirand, Christine, Huguet, Léa, Gorisse-Hussonnois, Lucie, Rose, Christiane, Allinquant, Bernadette
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086270/
https://ncbi.nlm.nih.gov/pubmed/24981783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-82
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