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Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A
BACKGROUND: The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined. RESULTS: We used primary neurons and mouse brain slices to show that SET is...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086270/ https://ncbi.nlm.nih.gov/pubmed/24981783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-82 |
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