Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

BACKGROUND: The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined. RESULTS: We used primary neurons and mouse brain slices to show that SET is...

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Bibliographic Details
Main Authors: Chasseigneaux, Stéphanie, Clamagirand, Christine, Huguet, Léa, Gorisse-Hussonnois, Lucie, Rose, Christiane, Allinquant, Bernadette
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086270/
https://ncbi.nlm.nih.gov/pubmed/24981783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-82
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