Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity

Nitric oxide (NO) inhalation has been reported to increase the oxygen affinity of sickle cell erythrocytes. Also, proposed allosteric mechanisms for hemoglobin, based on S-nitrosation of β-chain cysteine 93, raise the possibilty of altering the pathophysiology of sickle cell disease by inhibiting po...

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Main Authors: Gladwin, Mark T., Schechter, Alan N., Shelhamer, James H., Pannell, Lewis K., Conway, Deirdre A., Hrinczenko, Borys W., Nichols, James S., Pease-Fye, Margaret E., Noguchi, Constance T., Rodgers, Griffin P., Ognibene, Frederick P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC408559/
https://ncbi.nlm.nih.gov/pubmed/10510334
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