Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization

We previously demonstrated that inhaling nitric oxide (NO) increases the oxygen affinity of sickle red blood cells (RBCs) in patients with sickle cell disease (SCD). Our recent studies found that NO lowered the P(50) values of sickle hemoglobin (HbS) hemolysates but did not increase methemoglobin (m...

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Main Authors: Ikuta, Tohru, Thatte, Hemant S., Tang, Jay X., Mukerji, Ishita, Knee, Kelly, Bridges, Kenneth R., Wang, Sabina, Montero-Huerta, Pedro, Joshi, Ratan Mani, Head, C. Alvin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889650/
https://ncbi.nlm.nih.gov/pubmed/21457702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.03.013
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