Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization

We previously demonstrated that inhaling nitric oxide (NO) increases the oxygen affinity of sickle red blood cells (RBCs) in patients with sickle cell disease (SCD). Our recent studies found that NO lowered the P(50) values of sickle hemoglobin (HbS) hemolysates but did not increase methemoglobin (m...

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Autors principals: Ikuta, Tohru, Thatte, Hemant S., Tang, Jay X., Mukerji, Ishita, Knee, Kelly, Bridges, Kenneth R., Wang, Sabina, Montero-Huerta, Pedro, Joshi, Ratan Mani, Head, C. Alvin
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889650/
https://ncbi.nlm.nih.gov/pubmed/21457702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.03.013
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