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Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerabilit...

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Detalhes bibliográficos
Main Authors: Aldrin-Kirk, Patrick, Davidsson, Marcus, Holmqvist, Staffan, Li, Jia-Yi, Björklund, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085060/
https://ncbi.nlm.nih.gov/pubmed/24999658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100869
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