BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription. Recently, BET inhibitors (BETi) have been developed that show promise as potent anticancer drugs against various solid and hematological malignancies. Here we s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Bhadury, Joydeep, Nilsson, Lisa M., Veppil Muralidharan, Somsundar, Green, Lydia C., Li, Zhoulei, Gesner, Emily M., Hansen, Henrik C., Keller, Ulrich B., McLure, Kevin G., Nilsson, Jonas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084424/
https://ncbi.nlm.nih.gov/pubmed/24979794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406722111
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge