BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription. Recently, BET inhibitors (BETi) have been developed that show promise as potent anticancer drugs against various solid and hematological malignancies. Here we s...

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Detalhes bibliográficos
Main Authors: Bhadury, Joydeep, Nilsson, Lisa M., Veppil Muralidharan, Somsundar, Green, Lydia C., Li, Zhoulei, Gesner, Emily M., Hansen, Henrik C., Keller, Ulrich B., McLure, Kevin G., Nilsson, Jonas A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084424/
https://ncbi.nlm.nih.gov/pubmed/24979794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406722111
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