BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression

Although the MYC oncogenic network represents an attractive therapeutic target for lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of epigenetic/ transcriptional regulators, particularly the bromodomain and extraterminal (BET) family, have been used to modulate MYC...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Cummin, Thomas E. C., Cox, Kerry L., Murray, Tom D., Turaj, Anna H., Dunning, Lisa, English, Vikki L., Fell, Rachel, Packham, Graham, Ma, Yan, Powell, Ben, Johnson, Peter W. M., Cragg, Mark S., Carter, Matthew J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391160/
https://ncbi.nlm.nih.gov/pubmed/32717030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002231
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