BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression

Although the MYC oncogenic network represents an attractive therapeutic target for lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of epigenetic/ transcriptional regulators, particularly the bromodomain and extraterminal (BET) family, have been used to modulate MYC...

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Detalles Bibliográficos
Publicado en:Blood Adv
Autores principales: Cummin, Thomas E. C., Cox, Kerry L., Murray, Tom D., Turaj, Anna H., Dunning, Lisa, English, Vikki L., Fell, Rachel, Packham, Graham, Ma, Yan, Powell, Ben, Johnson, Peter W. M., Cragg, Mark S., Carter, Matthew J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2020
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391160/
https://ncbi.nlm.nih.gov/pubmed/32717030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002231
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