BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression

Although the MYC oncogenic network represents an attractive therapeutic target for lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of epigenetic/ transcriptional regulators, particularly the bromodomain and extraterminal (BET) family, have been used to modulate MYC...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Cummin, Thomas E. C., Cox, Kerry L., Murray, Tom D., Turaj, Anna H., Dunning, Lisa, English, Vikki L., Fell, Rachel, Packham, Graham, Ma, Yan, Powell, Ben, Johnson, Peter W. M., Cragg, Mark S., Carter, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391160/
https://ncbi.nlm.nih.gov/pubmed/32717030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002231
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