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Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models

Copanlisib is a pan–class I phosphoinositide 3-kinase (PI3K) inhibitor with preferred activity toward PI3Kα and PI3Kδ. Despite the clear overall clinical benefit, the number of patients achieving complete remissions with the single agent is relatively low, a problem shared by the vast majority of ta...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Tarantelli, Chiara, Lange, Martin, Gaudio, Eugenio, Cascione, Luciano, Spriano, Filippo, Kwee, Ivo, Arribas, Alberto J., Rinaldi, Andrea, Jourdan, Thibaud, Berthold, Melanie, Sturz, Andrea, Sperl, Carolyn, Margheriti, Francesco, Scalise, Lorenzo, Gritti, Giuseppe, Rossi, Davide, Stathis, Anastasios, Liu, Ningshu, Zucca, Emanuele, Politz, Oliver, Bertoni, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065481/
https://ncbi.nlm.nih.gov/pubmed/32126142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000844
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