Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection

Seeded conversion of tau monomers into fibrils is a central step in the progression of tau pathology in Alzheimer’s disease and other neurodegenerative disorders. Self-assembly is mediated by the microtubule binding repeats in tau of which either three or four are present, depending on the protein i...

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Main Authors: Meyer, Virginia, Dinkel, Paul D., Luo, Yin, Yu, Xiang, Wei, Guanghong, Zheng, Jie, Eaton, Gareth R., Ma, Buyong, Nussinov, Ruth, Eaton, Sandra S., Margittai, Martin
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083751/
https://ncbi.nlm.nih.gov/pubmed/24453187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201308473
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