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Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection
Seeded conversion of tau monomers into fibrils is a central step in the progression of tau pathology in Alzheimer’s disease and other neurodegenerative disorders. Self-assembly is mediated by the microtubule binding repeats in tau of which either three or four are present, depending on the protein i...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083751/ https://ncbi.nlm.nih.gov/pubmed/24453187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201308473 |
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