Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau

[Image: see text] Tau pathology in Alzheimer’s disease is intimately linked to the deposition of proteinacious filaments, which akin to infectious prions, have been proposed to spread via seeded conversion. Here we use double electron–electron resonance (DEER) spectroscopy in combination with extens...

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Hlavní autoři: Siddiqua, Ayisha, Luo, Yin, Meyer, Virginia, Swanson, Michael A., Yu, Xiang, Wei, Guanghong, Zheng, Jie, Eaton, Gareth R., Ma, Buyong, Nussinov, Ruth, Eaton, Sandra S., Margittai, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381011/
https://ncbi.nlm.nih.gov/pubmed/22656332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303498q
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