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The distinct structural preferences of Tau protein repeat domains
The tau fibrillar structures from the brain of an Alzheimer’s patient have a core with C-shaped motif of third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for the R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appea...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986281/ https://ncbi.nlm.nih.gov/pubmed/29774342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc01263f |
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