Загрузка...

How Does Hyperphopsphorylation Promote Tau Aggregation and Modulate Filament Structure and Stability?

Tau proteins are hyperphosphorylated at common sites in their N- and C-terminal domains in at least three neurodegenerative diseases, Parkinson, dementia with Lewy bodies, and Alzheimer’s, suggesting specific pathology but general mechanism. Full-length human tau filament comprises a rigid core and...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :ACS Chem Neurosci
Главные авторы: Xu, Liang, Zheng, Jie, Margittai, Martin, Nussinov, Ruth, Ma, Buyong
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831686/
https://ncbi.nlm.nih.gov/pubmed/26854860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00294
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!