Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2

BACKGROUND: Metronomic cyclophosphamide given on an intermittent, 6-day repeating schedule, but not on an exposure dose-equivalent daily schedule, activates an anti-tumor innate immune response that leads to major regression of large implanted gliomas, without anti-angiogenesis. METHODS AND APPROACH...

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Hlavní autoři: Doloff, Joshua C, Chen, Chong-Sheng, Waxman, David J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083145/
https://ncbi.nlm.nih.gov/pubmed/24965046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-158
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