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Graded levels of IRF4 regulate CD8(+) T cell differentiation and expansion, but not attrition, in response to acute virus infection()

In response to acute virus infections, CD8(+) T cells differentiate to form a large population of short-lived effectors and a stable pool of long-lived memory cells. The characteristics of the CD8(+) T cell response are influenced by TCR affinity, antigen dose, and the inflammatory cytokine milieu d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nayar, Ribhu, Schutten, Elizabeth, Bautista, Bianca, Daniels, Keith, Prince, Amanda L., Enos, Megan, Brehm, Michael A., Swain, Susan L., Welsh, Raymond M., Berg, Leslie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080788/
https://ncbi.nlm.nih.gov/pubmed/24835398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303187
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