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IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8(+) T Cells Responding to Persistent LCMV Infection
CD8(+) T cell exhaustion commonly occurs in chronic infections and cancers. During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4699851/ https://ncbi.nlm.nih.gov/pubmed/26714260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144826 |
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