The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain()

Light chain (LC) amyloidosis (AL) is a fatal disease in which immunoglobulin LC deposit as fibrils. Although the LC amyloid-forming propensity is attributed primarily to the variable region, fibrils also contain full-length LC comprised of variable-joining (V(L)) and constant (C(L)) regions. To asse...

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Hlavní autoři: Klimtchuk, Elena S., Gursky, Olga, Patel, Rupesh S., Laporte, Kathryn L., Connors, Lawreen H., Skinner, Martha, Seldin, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080313/
https://ncbi.nlm.nih.gov/pubmed/20936823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101351c
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