The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain()

Light chain (LC) amyloidosis (AL) is a fatal disease in which immunoglobulin LC deposit as fibrils. Although the LC amyloid-forming propensity is attributed primarily to the variable region, fibrils also contain full-length LC comprised of variable-joining (V(L)) and constant (C(L)) regions. To asse...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Klimtchuk, Elena S., Gursky, Olga, Patel, Rupesh S., Laporte, Kathryn L., Connors, Lawreen H., Skinner, Martha, Seldin, David C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080313/
https://ncbi.nlm.nih.gov/pubmed/20936823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101351c
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