Discovery of a Dicer-Independent, Cell-Type Dependent Alternate Targeting Sequence Generator: Implications in Gene Silencing & Pooled RNAi Screens

There is an acceptance that plasmid-based delivery of interfering RNA always generates the intended targeting sequences in cells, making it as specific as its synthetic counterpart. However, recent studies have reported on cellular inefficiencies of the former, especially in light of emerging gene d...

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Autori principali: Bhinder, Bhavneet, Shum, David, Li, Mu, Ibáñez, Glorymar, Vlassov, Alexander V., Magdaleno, Susan, Djaballah, Hakim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079264/
https://ncbi.nlm.nih.gov/pubmed/24987961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100676
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