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Discovery of a Dicer-Independent, Cell-Type Dependent Alternate Targeting Sequence Generator: Implications in Gene Silencing & Pooled RNAi Screens

There is an acceptance that plasmid-based delivery of interfering RNA always generates the intended targeting sequences in cells, making it as specific as its synthetic counterpart. However, recent studies have reported on cellular inefficiencies of the former, especially in light of emerging gene d...

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Detalhes bibliográficos
Main Authors: Bhinder, Bhavneet, Shum, David, Li, Mu, Ibáñez, Glorymar, Vlassov, Alexander V., Magdaleno, Susan, Djaballah, Hakim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079264/
https://ncbi.nlm.nih.gov/pubmed/24987961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100676
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