Unexpected link between an antibiotic, pannexin channels, and apoptosis

Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from apoptotic cells to attract phagocytes. In a small molecule screen, we discovered the quinolone antibiotic trovafloxacin as a novel PANX1 inhibitor. Although quinolones are widely used to treat bacterial infections, s...

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Hlavní autoři: Poon, Ivan K. H., Chiu, Yu-Hsin, Armstrong, Allison J., Kinchen, Jason M., Juncadella, Ignacio J., Bayliss, Douglas A., Ravichandran, Kodi S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078991/
https://ncbi.nlm.nih.gov/pubmed/24646995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13147
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