Pannexin 1 channels mediate ‘find–me’ signal release and membrane permeability during apoptosis

Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes1. The nucleotides ATP and UTP represent one class of find-me signals2, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-m...

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Detalhes bibliográficos
Main Authors: Chekeni, Faraaz B., Elliott, Michael R., Sandilos, Joanna K., Walk, Scott F., Kinchen, Jason M., Lazarowski, Eduardo R., Armstrong, Allison J., Penuela, Silvia, Laird, Dale W., Salvesen, Guy S., Isakson, Brant E., Bayliss, Douglas A., Ravichandran, Kodi S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006164/
https://ncbi.nlm.nih.gov/pubmed/20944749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09413
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