Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

Pannexin 1 (PANX1) channels mediate release of ATP, a “find-me” signal that recruits macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated cleavage of PANX1 at its C terminus, but how the C terminus inhibits basal channel activity is not understood. Here, we pro...

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Main Authors: Sandilos, Joanna K., Chiu, Yu-Hsin, Chekeni, Faraaz B., Armstrong, Allison J., Walk, Scott F., Ravichandran, Kodi S., Bayliss, Douglas A.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Membrane Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322839/
https://ncbi.nlm.nih.gov/pubmed/22311983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323378
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