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Unexpected link between an antibiotic, pannexin channels, and apoptosis
Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from apoptotic cells to attract phagocytes. In a small molecule screen, we discovered the quinolone antibiotic trovafloxacin as a novel PANX1 inhibitor. Although quinolones are widely used to treat bacterial infections, s...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078991/ https://ncbi.nlm.nih.gov/pubmed/24646995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13147 |
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