Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes

Islet-level oxidative stress has been proposed as a trigger for type 1 diabetes (T1D), and release of cytokines by infiltrating immune cells further elevates reactive oxygen species (ROS), exacerbating β cell duress. To identify genes/mechanisms involved with diabeto-genesis at the β cell level, gen...

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Bibliografiske detaljer
Main Authors: Bogdani, Marika, Henschel, Angela M., Kansra, Sanjay, Fuller, Jessica M., Geoffrey, Rhonda, Jia, Shuang, Kaldunski, Mary L., Pavletich, Scott, Prosser, Simon, Chen, Yi-Guang, Lernmark, Åke, Hessner, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077722/
https://ncbi.nlm.nih.gov/pubmed/23111281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-12-0385
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