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Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates
AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and b...
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| Pubblicato in: | Diabetologia |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002022/ https://ncbi.nlm.nih.gov/pubmed/31907557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-05066-7 |
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