Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates

AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and how this affects the development of insulitis and b...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Bogdani, Marika, Speake, Cate, Dufort, Mathew J., Johnson, Pamela Y., Larmore, Megan J., Day, Anthony J., Wight, Thomas N., Lernmark, Åke, Greenbaum, Carla J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002022/
https://ncbi.nlm.nih.gov/pubmed/31907557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-05066-7
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