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Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats

Type 1 diabetes is associated with abberations of fat metabolism before and after the clinical onset of disease. It has been hypothesized that the absence of the effect of insulin in the liver contributes to reduced hepatic fat synthesis. We measured hepatic gene expression and serum metabolites bef...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Regnell, Simon E., Hessner, Martin J., Jia, Shuang, Åkesson, Lina, Stenlund, Hans, Moritz, Thomas, La Torre, Daria, Lernmark, Åke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305198/
https://ncbi.nlm.nih.gov/pubmed/28192442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171372
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