Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats

AIMS/HYPOTHESIS: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (...

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia
Main Authors: Medina, Anya, Parween, Saba, Ullsten, Sara, Vishnu, Neelanjan, Siu, Yuk Ting, Quach, My, Bennet, Hedvig, Balhuizen, Alexander, Åkesson, Lina, Wierup, Nils, Carlsson, Per Ola, Ahlgren, Ulf, Lernmark, Åke, Fex, Malin
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448977/
https://ncbi.nlm.nih.gov/pubmed/29209740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4512-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items