Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats

AIMS/HYPOTHESIS: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (...

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Publicado no:Diabetologia
Main Authors: Medina, Anya, Parween, Saba, Ullsten, Sara, Vishnu, Neelanjan, Siu, Yuk Ting, Quach, My, Bennet, Hedvig, Balhuizen, Alexander, Åkesson, Lina, Wierup, Nils, Carlsson, Per Ola, Ahlgren, Ulf, Lernmark, Åke, Fex, Malin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448977/
https://ncbi.nlm.nih.gov/pubmed/29209740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4512-z
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