Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we found that lenalidomide causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by t...

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Hlavní autoři: Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077049/
https://ncbi.nlm.nih.gov/pubmed/24292625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1244851
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