Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism. Akt hyperactivation contributes to many pathophysiological conditions, including human cancers(1–3), and is closely associated with poor prognosis and chemo- or radio-therapeutic resistance(4). Phosp...

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Bibliografiske detaljer
Main Authors: Liu, Pengda, Begley, Michael, Michowski, Wojciech, Inuzuka, Hiroyuki, Ginzberg, Miriam, Gao, Daming, Tsou, Peiling, Gan, Wenjian, Papa, Antonella, Kim, Byeong Mo, Wan, Lixin, Singh, Amrik, Zhai, Bo, Yuan, Min, Wang, Zhiwei, Gygi, Steven P., Lee, Tae Ho, Lu, Kun-Ping, Toker, Alex, Pandolfi, Pier Paolo, Asara, John M., Kirschner, Marc W., Sicinski, Piotr, Cantley, Lewis, Wei, Wenyi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076493/
https://ncbi.nlm.nih.gov/pubmed/24670654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13079
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