Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism. Akt hyperactivation contributes to many pathophysiological conditions, including human cancers(1–3), and is closely associated with poor prognosis and chemo- or radio-therapeutic resistance(4). Phosp...

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Hlavní autoři: Liu, Pengda, Begley, Michael, Michowski, Wojciech, Inuzuka, Hiroyuki, Ginzberg, Miriam, Gao, Daming, Tsou, Peiling, Gan, Wenjian, Papa, Antonella, Kim, Byeong Mo, Wan, Lixin, Singh, Amrik, Zhai, Bo, Yuan, Min, Wang, Zhiwei, Gygi, Steven P., Lee, Tae Ho, Lu, Kun-Ping, Toker, Alex, Pandolfi, Pier Paolo, Asara, John M., Kirschner, Marc W., Sicinski, Piotr, Cantley, Lewis, Wei, Wenyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076493/
https://ncbi.nlm.nih.gov/pubmed/24670654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13079
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