Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism. Akt hyperactivation contributes to many pathophysiological conditions, including human cancers(1–3), and is closely associated with poor prognosis and chemo- or radio-therapeutic resistance(4). Phosp...

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Autores principales: Liu, Pengda, Begley, Michael, Michowski, Wojciech, Inuzuka, Hiroyuki, Ginzberg, Miriam, Gao, Daming, Tsou, Peiling, Gan, Wenjian, Papa, Antonella, Kim, Byeong Mo, Wan, Lixin, Singh, Amrik, Zhai, Bo, Yuan, Min, Wang, Zhiwei, Gygi, Steven P., Lee, Tae Ho, Lu, Kun-Ping, Toker, Alex, Pandolfi, Pier Paolo, Asara, John M., Kirschner, Marc W., Sicinski, Piotr, Cantley, Lewis, Wei, Wenyi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076493/
https://ncbi.nlm.nih.gov/pubmed/24670654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13079
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