Trp53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath Tumorigenesis

Malignant peripheral nerve sheath tumors (MPNSTs) are genetically diverse, aggressive sarcomas that occur sporadically or in association with neurofibromatosis type 1 syndrome. Reduced TP53 gene expression and amplification/overexpression of the epidermal growth factor receptor (EGFR) gene occur in...

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Detalhes bibliográficos
Main Authors: Rahrmann, Eric P., Moriarity, Branden S., Otto, George M., Watson, Adrienne L., Choi, Kwangmin, Collins, Margaret H., Wallace, Margaret, Webber, Beau R., Forster, Colleen L., Rizzardi, Anthony E., Schmechel, Stephen C., Ratner, Nancy, Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076465/
https://ncbi.nlm.nih.gov/pubmed/24832557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.04.006
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