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Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T-cell activation is poorly understood. We have shown that naïve T-cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency i...

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書誌詳細
主要な著者: Nakaya, Mako, Xiao, Yichuan, Zhou, Xiaofei, Chang, Jae-Hoon, Chang, Mikyoung, Cheng, Xuhong, Blonska, Marzenna, Lin, Xin, Sun, Shao-Cong
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074507/
https://ncbi.nlm.nih.gov/pubmed/24792914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.007
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