TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling

Development of autoimmune diseases, such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), involves the inflammatory action of Th1 and Th17 cells, but the underlying signaling mechanism is incompletely understood. We show that the kinase TPL2 is a crucial mediator of EAE and...

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Hauptverfasser: Xiao, Yichuan, Jin, Jin, Chang, Mikyoung, Nakaya, Mako, Hu, Hongbo, Zou, Qiang, Zhou, Xiaofei, Brittain, George C., Cheng, Xuhong, Sun, Shao-Cong
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113941/
https://ncbi.nlm.nih.gov/pubmed/24980047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132640
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