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TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling
Development of autoimmune diseases, such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), involves the inflammatory action of Th1 and Th17 cells, but the underlying signaling mechanism is incompletely understood. We show that the kinase TPL2 is a crucial mediator of EAE and...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113941/ https://ncbi.nlm.nih.gov/pubmed/24980047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132640 |
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