Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T-cell activation is poorly understood. We have shown that naïve T-cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nakaya, Mako, Xiao, Yichuan, Zhou, Xiaofei, Chang, Jae-Hoon, Chang, Mikyoung, Cheng, Xuhong, Blonska, Marzenna, Lin, Xin, Sun, Shao-Cong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074507/
https://ncbi.nlm.nih.gov/pubmed/24792914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.007
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